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- Title
Oscillations in NF-kappaB signaling control the dynamics of gene expression.
- Authors
Nelson, D E; Ihekwaba, A E C; Elliott, M; Johnson, J R; Gibney, C A; Foreman, B E; Nelson, G; See, V; Horton, C A; Spiller, D G; Edwards, S W; McDowell, H P; Unitt, J F; Sullivan, E; Grimley, R; Benson, N; Broomhead, D; Kell, D B; White, M R H
- Abstract
Signaling by the transcription factor nuclear factor kappa B (NF-kappaB) involves its release from inhibitor kappa B (IkappaB) in the cytosol, followed by translocation into the nucleus. NF-kappaB regulation of IkappaBalpha transcription represents a delayed negative feedback loop that drives oscillations in NF-kappaB translocation. Single-cell time-lapse imaging and computational modeling of NF-kappaB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IkappaBalpha transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-kappaB signaling may thus depend on number, period, and amplitude of oscillations.
- Publication
Science (New York, N.Y.), 2004, Vol 306, Issue 5696, p704
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1099962