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- Title
Gastric cancer originating from bone marrow-derived cells.
- Authors
Houghton, Jeanmarie; Stoicov, Calin; Nomura, Sachiyo; Rogers, Arlin B; Carlson, Jane; Li, Hanchen; Cai, Xun; Fox, James G; Goldenring, James R; Wang, Timothy C
- Abstract
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.
- Publication
Science (New York, N.Y.), 2004, Vol 306, Issue 5701, p1568
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1099513