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- Title
Defining a link with asthma in mice congenitally deficient in eosinophils.
- Authors
Lee, James J; Dimina, Dawn; Macias, MiMi P; Ochkur, Sergei I; McGarry, Michael P; O'Neill, Katie R; Protheroe, Cheryl; Pero, Ralph; Nguyen, Thanh; Cormier, Stephania A; Lenkiewicz, Elizabeth; Colbert, Dana; Rinaldi, Lisa; Ackerman, Steven J; Irvin, Charles G; Lee, Nancy A
- Abstract
Eosinophils are often dominant inflammatory cells present in the lungs of asthma patients. Nonetheless, the role of these leukocytes remains poorly understood. We have created a transgenic line of mice (PHIL) that are specifically devoid of eosinophils, but otherwise have a full complement of hematopoietically derived cells. Allergen challenge of PHIL mice demonstrated that eosinophils were required for pulmonary mucus accumulation and the airway hyperresponsiveness associated with asthma. The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis.
- Publication
Science (New York, N.Y.), 2004, Vol 305, Issue 5691, p1773
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1099472