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- Title
Lack of a fusion requirement for development of bone marrow-derived epithelia.
- Authors
Harris, Robert G; Herzog, Erica L; Bruscia, Emanuela M; Grove, Joanna E; Van Arnam, John S; Krause, Diane S
- Abstract
Analysis of developmental plasticity of bone marrow-derived cells (BMDCs) is complicated by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop from BMDCs without cell-cell fusion. We use the Cre/lox system together with beta-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion.
- Publication
Science (New York, N.Y.), 2004, Vol 305, Issue 5680, p90
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1098925