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- Title
Advanced cardiac morphogenesis does not require heart tube fusion.
- Authors
Li, Shanru; Zhou, Deying; Lu, Min Min; Morrisey, Edward E
- Abstract
The bilateral cardiac mesoderm migrates from the lateral region of the embryo to the ventral midline, where it fuses to form the primitive heart tube. It is generally accepted that migration and fusion are essential for subsequent stages of cardiac morphogenesis. We present evidence that, in Foxp4 mutant embryonic mice, each bilateral heart-forming region is capable of developing into a highly differentiated four-chambered mammalian heart in the absence of midline fusion. These data demonstrate that left-right chamber specification, cardiac looping, septation, cardiac myocyte differentiation, and endocardial cushion formation are preprogrammed in the precardiac mesoderm and do not require midline positional identity or heart tube fusion.
- Publication
Science (New York, N.Y.), 2004, Vol 305, Issue 5690, p1619
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1098674