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- Title
Salmonella modulates vesicular traffic by altering phosphoinositide metabolism.
- Authors
Hernandez, Lorraine D; Hueffer, Karsten; Wenk, Markus R; Galán, Jorge E
- Abstract
Salmonella enterica, the cause of food poisoning and typhoid fever, induces actin cytoskeleton rearrangements and membrane ruffling to gain access into nonphagocytic cells, where it can replicate and avoid innate immune defenses. Here, we found that SopB, a phosphoinositide phosphatase that is delivered into host cells by a type III secretion system, was essential for the establishment of Salmonella's intracellular replicative niche. SopB mediated the formation of spacious phagosomes following bacterial entry and was responsible for maintaining high levels of phosphatidylinositol-three-phosphate [PtdIns(3)P] in the membrane of the bacteria-containing vacuoles. Absence of SopB caused a significant defect in the maturation of the Salmonella-containing vacuole and impaired bacterial intracellular growth.
- Publication
Science (New York, N.Y.), 2004, Vol 304, Issue 5678, p1805
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1098188