We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mapping the antigenic and genetic evolution of influenza virus.
- Authors
Smith, Derek J; Lapedes, Alan S; de Jong, Jan C; Bestebroer, Theo M; Rimmelzwaan, Guus F; Osterhaus, Albert D M E; Fouchier, Ron A M
- Abstract
The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.
- Publication
Science (New York, N.Y.), 2004, Vol 305, Issue 5682, p371
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1097211