We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase.
- Authors
Chang, Chieh; Yu, Timothy W; Bargmann, Cornelia I; Tessier-Lavigne, Marc
- Abstract
During axon guidance, the ventral guidance of the Caenorhabditis elegans anterior ventral microtubule axon is controlled by two cues, the UNC-6/netrin attractant recognized by the UNC-40/DCC receptor and the SLT-1/slit repellent recognized by the SAX-3/robo receptor. We show here that loss-of-function mutations in clr-1 enhance netrin-dependent attraction, suppressing ventral guidance defects in slt-1 mutants. clr-1 encodes a transmembrane receptor protein tyrosine phosphatase (RPTP) that functions in AVM to inhibit signaling through the DCC family receptor UNC-40 and its effector, UNC-34/enabled. The known effects of other RPTPs in axon guidance could result from modulation of guidance receptors like UNC-40/DCC.
- Publication
Science (New York, N.Y.), 2004, Vol 305, Issue 5680, p103
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1096983