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- Title
The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.
- Authors
Scherz, Paul J; Harfe, Brian D; McMahon, Andrew P; Tabin, Clifford J
- Abstract
Vertebrate limb outgrowth is driven by a positive feedback loop involving Sonic Hedgehog (Shh), Gremlin, and Fgf4. By overexpressing individual components of the loop at a time after these genes are normally down-regulated in chicken embryos, we found that Shh no longer maintains Gremlin in the posterior limb. Shh-expressing cells and their descendants cannot express Gremlin. The proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells, which breaks down the Shh-Fgf4 loop and thereby affects limb size and provides a mechanism explaining regulative properties of the limb bud.
- Publication
Science (New York, N.Y.), 2004, Vol 305, Issue 5682, p396
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1096966