We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8.
- Authors
Yu, Li; Alva, Ajjai; Su, Helen; Dutt, Parmesh; Freundt, Eric; Welsh, Sarah; Baehrecke, Eric H; Lenardo, Michael J
- Abstract
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We define a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition. Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death.
- Publication
Science (New York, N.Y.), 2004, Vol 304, Issue 5676, p1500
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1096645