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- Title
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.
- Authors
Harvey, Robert J; Depner, Ulrike B; Wässle, Heinz; Ahmadi, Seifollah; Heindl, Cornelia; Reinold, Heiko; Smart, Trevor G; Harvey, Kirsten; Schütz, Burkhard; Abo-Salem, Osama M; Zimmer, Andreas; Poisbeau, Pierrick; Welzl, Hans; Wolfer, David P; Betz, Heinrich; Zeilhofer, Hanns Ulrich; Müller, Ulrike
- Abstract
Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR alpha3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization. We show that GlyR alpha3 is distinctly expressed in superficial layers of the spinal cord dorsal horn. Mice deficient in GlyR alpha3 not only lack the inhibition of glycinergic neurotransmission by PGE2 seen in wild-type mice but also show a reduction in pain sensitization induced by spinal PGE2 injection or peripheral inflammation. Thus, GlyR alpha3 may provide a previously unrecognized molecular target in pain therapy.
- Publication
Science (New York, N.Y.), 2004, Vol 304, Issue 5672, p884
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1094925