We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
- Authors
Nelson, W James; Nusse, Roel
- Abstract
The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, beta-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5663, p1483
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1094291