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- Title
Epigenetic dynamics of imprinted X inactivation during early mouse development.
- Authors
Okamoto, Ikuhiro; Otte, Arie P; Allis, C David; Reinberg, Danny; Heard, Edith
- Abstract
The initiation of X-chromosome inactivation is thought to be tightly correlated with early differentiation events during mouse development. Here, we show that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation. A reversal of the inactive state, with a loss of epigenetic marks such as histone modifications and polycomb proteins, subsequently occurs in cells of the inner cell mass (ICM), which give rise to the embryo-proper in which random X inactivation is known to occur. This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5658, p644
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1092727