We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inflammatory exposure and historical changes in human life-spans.
- Authors
Finch, Caleb E; Crimmins, Eileen M
- Abstract
Most explanations of the increase in life expectancy at older ages over history emphasize the importance of medical and public health factors of a particular historical period. We propose that the reduction in lifetime exposure to infectious diseases and other sources of inflammation--a cohort mechanism--has also made an important contribution to the historical decline in old-age mortality. Analysis of birth cohorts across the life-span since 1751 in Sweden reveals strong associations between early-age mortality and subsequent mortality in the same cohorts. We propose that a "cohort morbidity phenotype" represents inflammatory processes that persist from early age into adult life.
- Publication
Science (New York, N.Y.), 2004, Vol 305, Issue 5691, p1736
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1092556