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- Title
Regulation of fasted blood glucose by resistin.
- Authors
Banerjee, Ronadip R; Rangwala, Shamina M; Shapiro, Jennifer S; Rich, A Sophie; Rhoades, Ben; Qi, Yong; Wang, Juan; Rajala, Michael W; Pocai, Alessandro; Scherer, Phillipp E; Steppan, Claire M; Ahima, Rexford S; Obici, Silvana; Rossetti, Luciano; Lazar, Mitchell A
- Abstract
The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate-activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5661, p1195
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1092341