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- Title
MicroRNAs modulate hematopoietic lineage differentiation.
- Authors
Chen, Chang-Zheng; Li, Ling; Lodish, Harvey F; Bartel, David P
- Abstract
MicroRNAs (miRNAs) are an abundant class of approximately 22-nucleotide regulatory RNAs found in plants and animals. Some miRNAs of plants, Caenorhabditis elegans, and Drosophila play important gene-regulatory roles during development by pairing to target mRNAs to specify posttranscriptional repression of these messages. We identify three miRNAs that are specifically expressed in hematopoietic cells and show that their expression is dynamically regulated during early hematopoiesis and lineage commitment. One of these miRNAs, miR-181, was preferentially expressed in the B-lymphoid cells of mouse bone marrow, and its ectopic expression in hematopoietic stem/progenitor cells led to an increased fraction of B-lineage cells in both tissue-culture differentiation assays and adult mice. Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5654, p83
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1091903