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Title
Medicine. PPARs as therapeutic targets: reverse cardiology?
Authors
Plutzky, Jorge
Abstract
Formation of the atherosclerotic lesions that lead to myocardial infarction is determined in part by inflammatory responses such as the production of lipid-laden macrophages. In his Perspective, Plutzky highlights the parts played by PPAR nuclear receptors, especially PPAR-delta (Lee et al.), in the modulation of inflammatory responses and hence atherosclerosis.
Publication
Science (New York, N.Y.), 2003, Vol 302, Issue 5644, p406