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- Title
Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus.
- Authors
Weigel, Linda M; Clewell, Don B; Gill, Steven R; Clark, Nancye C; McDougal, Linda K; Flannagan, Susan E; Kolonay, James F; Shetty, Jyoti; Killgore, George E; Tenover, Fred C
- Abstract
Vancomycin is usually reserved for treatment of serious infections, including those caused by multidrug-resistant Staphylococcus aureus. A clinical isolate of S. aureus with high-level resistance to vancomycin (minimal inhibitory concentration = 1024 microg/ml) was isolated in June 2002. This isolate harbored a 57.9-kilobase multiresistance conjugative plasmid within which Tn1546 (vanA) was integrated. Additional elements on the plasmid encoded resistance to trimethoprim (dfrA), beta-lactams (blaZ), aminoglycosides (aacA-aphD), and disinfectants (qacC). Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn1546 from a co-isolate of Enterococcus faecalis.
- Publication
Science (New York, N.Y.), 2003, Vol 302, Issue 5650, p1569
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1090956