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- Title
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.
- Authors
Bhowmick, Neil A; Chytil, Anna; Plieth, David; Gorska, Agnieszka E; Dumont, Nancy; Shappell, Scott; Washington, M Kay; Neilson, Eric G; Moses, Harold L
- Abstract
Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor-beta (TGF-beta) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-beta type II receptor gene in mouse fibroblasts (Tgfbr2fspKO). The loss of TGF-beta responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an increased abundance of stromal cells. Activation of paracrine hepatocyte growth factor (HGF) signaling was identified as one possible mechanism for stimulation of epithelial proliferation. Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5659, p848
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1090922