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- Title
Structural basis of transcription: separation of RNA from DNA by RNA polymerase II.
- Authors
Westover, Kenneth D; Bushnell, David A; Kornberg, Roger D
- Abstract
The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5660, p1014
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1090839