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- Title
Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase.
- Authors
Ruefli-Brasse, Astrid A; French, Dorothy M; Dixit, Vishva M
- Abstract
Paracaspase (MALT1), a member of an evolutionarily conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10 in vitro and, because of this association, has been suggested to be involved in the CARMA1-Bcl10 pathway of antigen-induced nuclear factor kappaB (NF-kappaB) activation. We demonstrate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation. Paracaspase acts downstream of Bcl10 to induce NF-kappaB activation and is required for the normal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and activation of the IkappaB kinase complex.
- Publication
Science (New York, N.Y.), 2003, Vol 302, Issue 5650, p1581
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1090769