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- Title
Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses.
- Authors
Tomita, Susumu; Fukata, Masaki; Nicoll, Roger A; Bredt, David S
- Abstract
Activity-dependent plasticity in the brain arises in part from changes in the number of synaptic AMPA receptors. Synaptic trafficking of AMPA receptors is controlled by stargazin and homologous transmembrane AMPA receptor regulatory proteins (TARPs). We found that TARPs were stable at the plasma membrane, whereas AMPA receptors were internalized in a glutamate-regulated manner. Interaction with AMPA receptors involved both extra- and intracellular determinants of TARPs. Upon binding to glutamate, AMPA receptors detached from TARPs. This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from TARPs may participate in glutamate-mediated internalization of receptors in synaptic plasticity.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5663, p1508
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1090262