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- Title
Control of effector CD8+ T cell function by the transcription factor Eomesodermin.
- Authors
Pearce, Erika L; Mullen, Alan C; Martins, Gislâine A; Krawczyk, Connie M; Hutchins, Anne S; Zediak, Valerie P; Banica, Monica; DiCioccio, Catherine B; Gross, Darrick A; Mao, Chai-An; Shen, Hao; Cereb, Nezih; Yang, Soo Y; Lindsten, Tullia; Rossant, Janet; Hunter, Christopher A; Reiner, Steven L
- Abstract
Activated CD8+ T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8+ T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8+ T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8+ T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.
- Publication
Science (New York, N.Y.), 2003, Vol 302, Issue 5647, p1041
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1090148