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- Title
Extensive gene traffic on the mammalian X chromosome.
- Authors
Emerson, J J; Kaessmann, Henrik; Betrán, Esther; Long, Manyuan
- Abstract
Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with mutational bias and is likely driven by natural selection to attain male germline function. However, the excess recruitment is consistent with a combination of both natural selection and mutational bias.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5657, p537
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1090042