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- Title
Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.
- Authors
Aizawa, Hiroyuki; Hu, Shu-Ching; Bobb, Kathryn; Balakrishnan, Karthik; Ince, Gulayse; Gurevich, Inga; Cowan, Mitra; Ghosh, Anirvan
- Abstract
The lasting effects of neuronal activity on brain development involve calcium-dependent gene expression. Using a strategy called transactivator trap, we cloned a calcium-responsive transactivator called CREST (for calcium-responsive transactivator). CREST is a SYT-related nuclear protein that interacts with adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding protein (CBP) and is expressed in the developing brain. Mice that have a targeted disruption of the crest gene are viable but display defects in cortical and hippocampal dendrite development. Cortical neurons from crest mutant mice are compromised in calcium-dependent dendritic growth. Thus, calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5655, p197
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1089845