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- Title
Control of pancreas and liver gene expression by HNF transcription factors.
- Authors
Odom, Duncan T; Zizlsperger, Nora; Gordon, D Benjamin; Bell, George W; Rinaldi, Nicola J; Murray, Heather L; Volkert, Tom L; Schreiber, Jörg; Rolfe, P Alexander; Gifford, David K; Fraenkel, Ernest; Bell, Graeme I; Young, Richard A
- Abstract
The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets. We identified tissue-specific regulatory circuits formed by HNF1alpha, HNF4alpha, and HNF6 with other transcription factors, revealing how these factors function as master regulators of hepatocyte and islet transcription. Our results suggest how misregulation of HNF4alpha can contribute to type 2 diabetes.
- Publication
Science (New York, N.Y.), 2004, Vol 303, Issue 5662, p1378
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1089769