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- Title
Evidence for ozone formation in human atherosclerotic arteries.
- Authors
Wentworth, Paul, Jr; Nieva, Jorge; Takeuchi, Cindy; Galve, Roger; Wentworth, Anita D; Dilley, Ralph B; DeLaria, Giacomo A; Saven, Alan; Babior, Bernard M; Janda, Kim D; Eschenmoser, Albert; Lerner, Richard A
- Abstract
Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of carotid endarterectomy, suggesting that ozone production occurred during lesion development. Furthermore, advanced atherosclerotic plaques generate ozone when the leukocytes within the diseased arteries are activated in vitro. The steroids produced by cholesterol ozonolysis cause effects that are thought to be critical to the pathogenesis of atherosclerosis, including cytotoxicity, lipid-loading in macrophages, and deformation of the apolipoprotein B-100 secondary structure. We propose the trivial designation "atheronals" for this previously unrecognized class of steroids.
- Publication
Science (New York, N.Y.), 2003, Vol 302, Issue 5647, p1053
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1089525