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- Title
Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking.
- Authors
Dahan, Maxime; Lévi, Sabine; Luccardini, Camilla; Rostaing, Philippe; Riveau, Béatrice; Triller, Antoine
- Abstract
Semiconductor quantum dots (QDs) are nanometer-sized fluorescent probes suitable for advanced biological imaging. We used QDs to track individual glycine receptors (GlyRs) and analyze their lateral dynamics in the neuronal membrane of living cells for periods ranging from milliseconds to minutes. We characterized multiple diffusion domains in relation to the synaptic, perisynaptic, or extrasynaptic GlyR localization. The entry of GlyRs into the synapse by diffusion was observed and further confirmed by electron microscopy imaging of QD-tagged receptors.
- Publication
Science (New York, N.Y.), 2003, Vol 302, Issue 5644, p442
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1088525