We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation.
- Authors
Gebert, Bettina; Fischer, Wolfgang; Weiss, Evelyn; Hoffmann, Reinhard; Haas, Rainer
- Abstract
Helicobacter pylori (Hp) vacuolating cytotoxin VacA induces cellular vacuolation in epithelial cells. We found that VacA could efficiently block proliferation of T cells by inducing a G1/S cell cycle arrest. It interfered with the T cell receptor/interleukin-2 (IL-2) signaling pathway at the level of the Ca2+-calmodulin-dependent phosphatase calcineurin. Nuclear translocation of nuclear factor of activated T cells (NFAT), a transcription factor acting as a global regulator of immune response genes, was abrogated, resulting in down-regulation of IL-2 transcription. VacA partially mimicked the activity of the immunosuppressive drug FK506 by possibly inducing a local immune suppression, explaining the extraordinary chronicity of Hp infections.
- Publication
Science (New York, N.Y.), 2003, Vol 301, Issue 5636, p1099
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1086871