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- Title
The immunological synapse balances T cell receptor signaling and degradation.
- Authors
Lee, Kyeong-Hee; Dinner, Aaron R; Tu, Chun; Campi, Gabriele; Raychaudhuri, Subhadip; Varma, Rajat; Sims, Tasha N; Burack, W Richard; Wu, Hui; Wang, Julia; Kanagawa, Osami; Markiewicz, Mary; Allen, Paul M; Dustin, Michael L; Chakraborty, Arup K; Shaw, Andrey S
- Abstract
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.
- Publication
Science (New York, N.Y.), 2003, Vol 302, Issue 5648, p1218
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1086507