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- Title
Organizing axes in time and space; 25 years of colinear tinkering.
- Authors
Kmita, Marie; Duboule, Denis
- Abstract
During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the "Hox clock"). Recent advances in the knowledge of the underlying mechanisms reveal that the embryo uses a variety of strategies to implement this colinear process, depending on both the type and the evolutionary history of axial structures. The search for a universal mechanism has likely hampered our understanding of this enigmatic phenomenon, which may be caused by various and unrelated regulatory processes, as long as the final distribution of proteins (the HOX code) is preserved.
- Publication
Science (New York, N.Y.), 2003, Vol 301, Issue 5631, p331
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1085753