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- Title
A B cell-based sensor for rapid identification of pathogens.
- Authors
Rider, Todd H; Petrovick, Martha S; Nargi, Frances E; Harper, James D; Schwoebel, Eric D; Mathews, Richard H; Blanchard, David J; Bortolin, Laura T; Young, Albert M; Chen, Jianzhu; Hollis, Mark A
- Abstract
We report the use of genetically engineered cells in a pathogen identification sensor. This sensor uses B lymphocytes that have been engineered to emit light within seconds of exposure to specific bacteria and viruses. We demonstrated rapid screening of relevant samples and identification of a variety of pathogens at very low levels. Because of its speed, sensitivity, and specificity, this pathogen identification technology could prove useful for medical diagnostics, biowarfare defense, food- and water-quality monitoring, and other applications.
- Publication
Science (New York, N.Y.), 2003, Vol 301, Issue 5630, p213
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1084920