We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
NompC TRP channel required for vertebrate sensory hair cell mechanotransduction.
- Authors
Sidi, Samuel; Friedrich, Rainer W; Nicolson, Teresa
- Abstract
The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.
- Publication
Science (New York, N.Y.), 2003, Vol 301, Issue 5629, p96
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1084370