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- Title
DAF-16 target genes that control C. elegans life-span and metabolism.
- Authors
Lee, Siu Sylvia; Kennedy, Scott; Tolonen, Andrew C; Ruvkun, Gary
- Abstract
Signaling from the DAF-2/insulin receptor to the DAF-16/FOXO transcription factor controls longevity, metabolism, and development in disparate phyla. To identify genes that mediate the conserved biological outputs of daf-2/insulin-like signaling, we used comparative genomics to identify 17 orthologous genes from Caenorhabditis and Drosophila, each of which bears a DAF-16 binding site in the promoter region. One-third of these DAF-16 downstream candidate genes were regulated by daf-2/insulin-like signaling in C. elegans, and RNA interference inactivation of the candidates showed that many of these genes mediate distinct aspects of daf-16 function, including longevity, metabolism, and development.
- Publication
Science (New York, N.Y.), 2003, Vol 300, Issue 5619, p644
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1083614