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- Title
Transcription start regions in the human genome are favored targets for MLV integration.
- Authors
Wu, Xiaolin; Li, Yuan; Crise, Bruce; Burgess, Shawn M
- Abstract
Factors contributing to retroviral integration have been intractable because past studies have not precisely located genomic sites of proviruses in sufficient numbers for significant analysis. In this study, 903 murine leukemia virus (MLV) and 379 human immunodeficiency virus-1 (HIV-1) integrations in the human genome were mapped. The data showed that MLV preferred integration near the start of transcriptional units (either upstream or downstream) whereas HIV-1 preferred integration anywhere in the transcriptional unit but not upstream of the transcriptional start. Defining different integration site preferences for retroviruses will have important ramifications for gene therapy and may aid in our understanding of the factors directing the integration process.
- Publication
Science (New York, N.Y.), 2003, Vol 300, Issue 5626, p1749
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1083413