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- Title
The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons.
- Authors
Lev-Maor, Galit; Sorek, Rotem; Shomron, Noam; Ast, Gil
- Abstract
Alu repetitive elements can be inserted into mature messenger RNAs via a splicing-mediated process termed exonization. To understand the molecular basis and the regulation of the process of turning intronic Alus into new exons, we compiled and analyzed a data set of human exonized Alus. We revealed a mechanism that governs 3' splice-site selection in these exons during alternative splicing. On the basis of these findings, we identified mutations that activated the exonization of a silent intronic Alu.
- Publication
Science (New York, N.Y.), 2003, Vol 300, Issue 5623, p1288
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1082588