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- Title
Stress-induced mutagenesis in bacteria.
- Authors
Bjedov, Ivana; Tenaillon, Olivier; Gérard, Bénédicte; Souza, Valeria; Denamur, Erick; Radman, Miroslav; Taddei, François; Matic, Ivan
- Abstract
The evolutionary significance of stress-induced mutagenesis was evaluated by studying mutagenesis in aging colonies (MAC) of Escherichia coli natural isolates. A large fraction of isolates exhibited a strong MAC, and the high MAC variability reflected the diversity of selective pressures in ecological niches. MAC depends on starvation, oxygen, and RpoS and adenosine 3',5'-monophosphate regulons; thus it may be a by-product of genetic strategies for improving survival under stress. MAC could also be selected through beneficial mutations that it generates, as shown by computer modeling and the patterns of stress-inducible and constitutive mutagenesis. We suggest that irrespective of the causes of their emergence, stress-induced mutations participate in adaptive evolution.
- Publication
Science (New York, N.Y.), 2003, Vol 300, Issue 5624, p1404
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1082240