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- Title
Identified sources and targets of slow inhibition in the neocortex.
- Authors
Tamás, Gábor; Lorincz, Andrea; Simon, Andrea; Szabadics, János
- Abstract
There are two types of inhibitory postsynaptic potentials in the cerebral cortex. Fast inhibition is mediated by ionotropic gamma-aminobutyric acid type A (GABA(A)) receptors, and slow inhibition is due to metabotropic GABA(B) receptors. Several neuron classes elicit inhibitory postsynaptic potentials through GABA(A) receptors, but possible distinct sources of slow inhibition remain unknown. We identified a class of GABAergic interneurons, the neurogliaform cells, that, in contrast to other GABA-releasing cells, elicited combined GABA(A) and GABA(B) receptor-mediated responses with single action potentials and that predominantly targeted the dendritic spines of pyramidal neurons. Slow inhibition evoked by a distinct interneuron in spatially restricted postsynaptic compartments could locally and selectively modulate cortical excitability.
- Publication
Science (New York, N.Y.), 2003, Vol 299, Issue 5614, p1902
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1082053