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- Title
Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.
- Authors
Paulsen, I T; Banerjei, L; Myers, G S A; Nelson, K E; Seshadri, R; Read, T D; Fouts, D E; Eisen, J A; Gill, S R; Heidelberg, J F; Tettelin, H; Dodson, R J; Umayam, L; Brinkac, L; Beanan, M; Daugherty, S; DeBoy, R T; Durkin, S; Kolonay, J; Madupu, R; Nelson, W; Vamathevan, J; Tran, B; Upton, J; Hansen, T; Shetty, J; Khouri, H; Utterback, T; Radune, D; Ketchum, K A; Dougherty, B A; Fraser, C M
- Abstract
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
- Publication
Science (New York, N.Y.), 2003, Vol 299, Issue 5615, p2071
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1080613