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- Title
A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.
- Authors
Xu, Jian; Bjursell, Magnus K; Himrod, Jason; Deng, Su; Carmichael, Lynn K; Chiang, Herbert C; Hooper, Lora V; Gordon, Jeffrey I
- Abstract
The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.
- Publication
Science (New York, N.Y.), 2003, Vol 299, Issue 5615, p2074
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1080029