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- Title
Control of regulatory T cell development by the transcription factor Foxp3.
- Authors
Hori, Shohei; Nomura, Takashi; Sakaguchi, Shimon
- Abstract
Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+ regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells.
- Publication
Science (New York, N.Y.), 2003, Vol 299, Issue 5609, p1057
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1079490