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- Title
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle.
- Authors
Molinari, Maurizio; Calanca, Verena; Galli, Carmela; Lucca, Paola; Paganetti, Paolo
- Abstract
The mechanisms that determine how folding attempts are interrupted to target folding-incompetent proteins for endoplasmic reticulum-associated degradation (ERAD) are poorly defined. Here the alpha-mannosidase I-like protein EDEM was shown to extract misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. EDEM overexpression resulted in faster release of folding-incompetent proteins from the calnexin cycle and earlier onset of degradation, whereas EDEM down-regulation prolonged folding attempts and delayed ERAD. Up-regulation of EDEM during ER stress may promote cell recovery by clearing the calnexin cycle and by accelerating ERAD of terminally misfolded polypeptides.
- Publication
Science (New York, N.Y.), 2003, Vol 299, Issue 5611, p1397
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1079474