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- Title
Regulation of chromatin remodeling by inositol polyphosphates.
- Authors
Steger, David J; Haswell, Elizabeth S; Miller, Aimee L; Wente, Susan R; O'Shea, Erin K
- Abstract
Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine triphosphate-dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.
- Publication
Science (New York, N.Y.), 2003, Vol 299, Issue 5603, p114
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1078062