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- Title
Ectoderm to mesoderm lineage switching during axolotl tail regeneration.
- Authors
Echeverri, Karen; Tanaka, Elly M
- Abstract
Foreign environments may induce adult stem cells to switch lineages and populate multiple tissue types, but whether this mechanism is used for tissue repair remains uncertain. Urodele amphibians can regenerate fully functional, multitissue structures including the limb and tail. To determine whether lineage switching is an integral feature of this regeneration, we followed individual spinal cord cells live during tail regeneration in the axolotl. Spinal cord cells frequently migrate into surrounding tissue to form regenerating muscle and cartilage. Thus, in axolotls, cells switch lineage during a real example of regeneration.
- Publication
Science (New York, N.Y.), 2002, Vol 298, Issue 5600, p1993
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1077804