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- Title
Interfaces between the detection, signaling, and repair of DNA damage.
- Authors
Rouse, John; Jackson, Stephen P
- Abstract
Left unrepaired, the myriad types of damage that can occur in genomic DNA pose a serious threat to the faithful transmission of the correct complement of genetic material. Defects in DNA damage signaling and repair result in genomic instability, a hallmark of cancer, and often cause lethality, underlining the importance of these processes in the cell and whole organism. The past decade has seen huge advances in our understanding of how the signal transduction pathways triggered by DNA damage radically alter cell behavior. In contrast, it is still unclear how primary DNA damage is detected and how this interfaces with signal transduction and DNA repair proteins.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5581, p547
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1074740