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- Title
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization.
- Authors
Lassus, Patrice; Opitz-Araya, Ximena; Lazebnik, Yuri
- Abstract
A current view is that cytotoxic stress, such as DNA damage, induces apoptosis by regulating the permeability of mitochondria. Mitochondria sequester several proteins that, if released, kill by activating caspases, the proteases that disassemble the cell. Cytokines activate caspases in a different way, by assembling receptor complexes that activate caspases directly; in this case, the subsequent mitochondrial permeabilization accelerates cell disassembly by amplifying caspase activity. We found that cytotoxic stress causes activation of caspase-2, and that this caspase is required for the permeabilization of mitochondria. Therefore, we argue that cytokine-induced and stress-induced apoptosis act through conceptually similar pathways in which mitochondria are amplifiers of caspase activity rather than initiators of caspase activation.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5585, p1352
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1074721