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- Title
Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase.
- Authors
Munn, David H; Sharma, Madhav D; Lee, Jeffrey R; Jhaver, Kanchan G; Johnson, Theodore S; Keskin, Derin B; Marshall, Brendan; Chandler, Phillip; Antonia, Scott J; Burgess, Russell; Slingluff, Craig L, Jr; Mellor, Andrew L
- Abstract
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5588, p1867
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1073514