We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Modulation of postendocytic sorting of G protein-coupled receptors.
- Authors
Whistler, Jennifer L; Enquist, Johan; Marley, Aaron; Fong, Jamie; Gladher, Fredrik; Tsuruda, Pamela; Murray, Stephen R; Von Zastrow, Mark
- Abstract
Recycling of the mu opioid receptor to the plasma membrane after endocytosis promotes rapid resensitization of signal transduction, whereas targeting of the delta opioid receptor (DOR) to lysosomes causes proteolytic down-regulation. We identified a protein that binds preferentially to the cytoplasmic tail of the DOR as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor-associated sorting protein (GASP). Disruption of the DOR-GASP interaction through receptor mutation or overexpression of a dominant negative fragment of GASP inhibited receptor trafficking to lysosomes and promoted recycling. The GASP family of proteins may modulate lysosomal sorting and functional down-regulation of a variety of G protein-coupled receptors.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5581, p615
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1073308