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- Title
Tissue-specific regulation of retinal and pituitary precursor cell proliferation.
- Authors
Li, Xue; Perissi, Valentina; Liu, Forrest; Rose, David W; Rosenfeld, Michael G
- Abstract
Mammalian organogenesis requires the expansion of pluripotent precursor cells before the subsequent determination of specific cell types, but the tissue-specific molecular mechanisms that regulate the initial expansion of primordial cells remain poorly defined. We have genetically established that Six6 homeodomain factor, acting as a strong tissue-specific repressor, regulates early progenitor cell proliferation during mammalian retinogenesis and pituitary development. Six6, in association with Dach corepressors, regulates proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. These data reveal a molecular mechanism by which a tissue-specific transcriptional repressor-corepressor complex can provide an organ-specific strategy for physiological expansion of precursor populations.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5584, p1180
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1073263