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- Title
Mast cells: a cellular link between autoantibodies and inflammatory arthritis.
- Authors
Lee, David M; Friend, Daniel S; Gurish, Michael F; Benoist, Christophe; Mathis, Diane; Brenner, Michael B
- Abstract
Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5587, p1689
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1073176